Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28030321 | 0.92 | PIK3CD (0.36) | PIK3CD | |
| SCHEMBL28030946 | 0.85 | DDB1 (0.39) | PIK3CDALDH1A1MAPK1NPSR1LMNA | |
| SCHEMBL16597161 | 0.76 | ALDH1A1 (0.48) | PIK3CDALDH1A1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL27936623 | 0.76 | DDB1 (0.51) | PIK3CDALDH1A1MAPK1NPSR1LMNA | |
| SCHEMBL28822138 | 0.76 | HRH3 (0.39) | PIK3CD | |
| SCHEMBL25346369 | 0.76 | TNF (0.34) | ALDH1A1MAPK1NPSR1KMT2A | |
| SCHEMBL28030943 | 0.76 | DDB1 (0.38) | ALDH1A1MAPK1NPSR1KMT2A | |
| SCHEMBL28030926 | 0.76 | USP2 (0.38) | ELANE | |
| SCHEMBL27759269 | 0.73 | CNR2 (0.38) | ALDH1A1NPSR1CNR2MEN1HTT | |
| SCHEMBL16584875 | 0.73 | SMN1; SMN2 (0.41) | PIK3CDMAPTSMN1; SMN2NPSR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017212-A | 5-substituted quinazolinone derivatives using as antineoplastic agent | CELGENE CORP | 2015-11-04 | — | — | CN | disclosed |
| CN-104910133-A | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS | CELGENE CORP | 2015-09-16 | — | — | CN | disclosed |
| CN-104876908-A | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP | 2015-09-02 | — | — | CN | disclosed |