Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27621172 | 0.85 | POLB (0.38) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL28190932 | 0.78 | ALDH1A1 (0.49) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL28114959 | 0.77 | KMT2A (0.44) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL27621308 | 0.75 | TDP1 (0.39) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL6205026 | 0.74 | TDP1 (0.44) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL4332774 | 0.74 | ALDH1A1 (0.40) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL28114928 | 0.74 | ALDH1A1 (0.37) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL7763285 | 0.73 | ALDH1A1 (0.40) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL21633000 | 0.72 | PARP1 (0.40) | ALDH1A1POLBLMNATDP1KMT2A | |
| SCHEMBL28536993 | 0.72 | KMT2A (0.39) | ALDH1A1POLBLMNATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107250110-B | Novel compounds as inhibitors of transfection Rearrangement (RET) | 葛兰素史克知识产权发展有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-107250110-A | The noval chemical compound of (RET) inhibitor is reset as transfection | 葛兰素史克知识产权发展有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-105051027-A | Pyridine derivatives as rearranged during transfection (RET) kinase inhibitors | GLAXOSMITHKLINE IP DEV LTD | 2015-11-11 | — | — | CN | disclosed |