Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332774 | 0.86 | ALDH1A1 (0.40) | TDP1POLBKDM4ECTDSP1L3MBTL1 | |
| SCHEMBL2259930 | 0.84 | TSHR (0.46) | TDP1POLBKDM4EL3MBTL1GRIN2D | |
| SCHEMBL19547595 | 0.82 | GRIN2D (0.41) | TDP1POLBKDM4EGRIN2DGRIN3B | |
| SCHEMBL27621172 | 0.81 | POLB (0.38) | TDP1POLBKDM4ECTDSP1L3MBTL1 | |
| SCHEMBL28019068 | 0.81 | TDP1 (0.38) | TDP1POLBKDM4ECTDSP1L3MBTL1 | |
| SCHEMBL30597565 | 0.79 | ALDH1A1 (0.61) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3939543 | 0.79 | LMNA (0.42) | TDP1POLBKDM4EGRIN2DGRIN3B | |
| SCHEMBL27621308 | 0.79 | TDP1 (0.39) | TDP1POLBKDM4ECTDSP1L3MBTL1 | |
| SCHEMBL28845802 | 0.79 | BCAT2 (0.41) | TDP1POLBKDM4ECTDSP1L3MBTL1 | |
| SCHEMBL3347421 | 0.79 | ALDH1A1 (0.47) | TDP1POLBKDM4ECTDSP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |