Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2019272 | 0.93 | TSHR (0.53) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL31147007 | 0.92 | TSHR (0.52) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL756224 | 0.92 | TSHR (0.55) | TSHRHPGDALDH1A1TP53HIF1A | |
| Iodide SCHEMBL27992105 | 0.90 | TSHR (0.53) | TSHRHPGDALDH1A1TP53HIF1A | |
| Bromide SCHEMBL9403200 | 0.90 | TSHR (0.53) | TSHRHPGDALDH1A1TP53HIF1A | |
| Sulfuric Acid SCHEMBL28894455 | 0.85 | TSHR (0.49) | TSHRHPGDALDH1A1TP53HIF1A | |
| Acrylamide SCHEMBL1008385 | 0.85 | CHRM5 (0.58) | TSHRHPGDALDH1A1TP53HIF1A | |
| Sulfuric Acid SCHEMBL7901326 | 0.84 | TSHR (0.47) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL5239242 | 0.83 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL13791296 | 0.82 | TSHR (0.63) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110182881-B | Method for promoting release of supersaturated total dissolved gas by using flocculant | 四川大学 | 2021-09-17 | — | — | CN | disclosed |
| CN-105060445-B | Positive ion organosilicone polyacrylamide flocculant and preparing method thereof | 寇斌 | 2017-01-11 | — | — | CN | disclosed |
| CN-105060445-A | Positive ion organosilicone polyacrylamide flocculant and preparing method thereof | KOU BIN | 2015-11-18 | — | — | CN | disclosed |