Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135739 | 0.83 | HPGD (0.56) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL4569297 | 0.80 | HPGD (0.69) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13534577 | 0.79 | EGLN1 (0.59) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL28042363 | 0.78 | HPGD (0.63) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL28032381 | 0.78 | HPGD (0.57) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL22647187 | 0.77 | ALDH1A1 (0.55) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL31750072 | 0.76 | HPGD (0.52) | HPGDALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL31750086 | 0.76 | HPGD (0.52) | HPGDALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL14967252 | 0.76 | CYP4A11 (0.55) | HPGDALDH1A1NPC1L3MBTL1ATM | |
| SCHEMBL9416606 | 0.76 | NPC1 (0.82) | HPGDALDH1A1RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870435-A | Aryl and heteroaryl fused lactams | PFIZER | 2015-08-26 | — | — | CN | disclosed |