Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.63 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032381 | 0.89 | HPGD (0.57) | HPGDSLC6A5ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL25839479 | 0.88 | HPGD (0.68) | HPGDSLC6A5ALDH1A1LMNAGAA | |
| SCHEMBL798001 | 0.83 | RAB9A (0.61) | HPGDALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL15467467 | 0.83 | RAB9A (0.61) | HPGDALDH1A1LMNAGAAL3MBTL1 | |
| SCHEMBL28032443 | 0.81 | HPGD (0.54) | HPGDALDH1A1LMNAL3MBTL1NPC1 | |
| SCHEMBL4569297 | 0.81 | HPGD (0.69) | HPGDALDH1A1LMNANPC1RAB9A | |
| SCHEMBL16127889 | 0.81 | APEX1 (0.77) | HPGDALDH1A1LMNANPC1RAB9A | |
| SCHEMBL23984534 | 0.80 | HPGD (0.67) | HPGDALDH1A1LMNANPC1RAB9A | |
| SCHEMBL29433999 | 0.80 | HPGD (0.74) | HPGDALDH1A1LMNANPC1RAB9A | |
| SCHEMBL7655589 | 0.80 | HPGD (0.74) | HPGDALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143215-A | Bruton's tyrosine kinase inhibitors | HOFFMANN LA ROCHE | 2015-12-09 | — | — | CN | disclosed |