Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Famotidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 3/20 | 0.98 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.98 |
| ▸ | CA12 | O43570 | 2/20 | 0.98 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.98 |
| ▸ | CA1 | P00915 | 2/20 | 0.98 |
| ▸ | CA2 | P00918 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | MAOA | P21397 | 2/20 | 0.98 |
| ▸ | CA4 | P22748 | 2/20 | 0.98 |
| ▸ | CA6 | P23280 | 2/20 | 0.98 |
| ▸ | CA5A | P35218 | 2/20 | 0.98 |
| ▸ | CA7 | P43166 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 2/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.98 |
| ▸ | POU5F1 | Q01860 | 2/20 | 0.98 |
| ▸ | CA9 | Q16790 | 2/20 | 0.98 |
| ▸ | SLC47A2 | Q86VL8 | 2/20 | 0.98 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.98 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Famotidine SCHEMBL458654 | 0.99 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL39237 | 0.99 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL29384901 | 0.99 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL973 | 0.99 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL1863201 | 0.98 | HRH2 (0.98) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL22127098 | 0.98 | HRH2 (0.98) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL1863206 | 0.97 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL7119657 | 0.97 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL28528271 | 0.97 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL9817308 | 0.97 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104906057-B | Preparation method of famotidine calcium and magnesium micro-pill type chewable tablets and products thereof | 西南药业股份有限公司 | 2018-03-02 | — | — | CN | claimed |
| CN-104971073-B | Preparation method of famotidine calcium and magnesium chewable tablets and products thereof | 西南药业股份有限公司 | 2018-01-12 | — | — | CN | claimed |
| CN-104906128-B | Compound famotidine calcium and magnesium chewable tablets and preparation method | 烟台荣昌制药股份有限公司 | 2017-08-11 | — | — | CN | claimed |
| CN-104095875-B | Famotidine calcium and magnesium chewable tablet | 烟台荣昌制药股份有限公司 | 2016-06-29 | — | — | CN | claimed |
| CN-104906057-B | Preparation method of famotidine calcium and magnesium micro-pill type chewable tablets and products thereof | 西南药业股份有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-104906057-B | Preparation method of famotidine calcium and magnesium micro-pill type chewable tablets and products thereof | 西南药业股份有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-104906057-B | Preparation method of famotidine calcium and magnesium micro-pill type chewable tablets and products thereof | 西南药业股份有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-104971073-B | Preparation method of famotidine calcium and magnesium chewable tablets and products thereof | 西南药业股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104971073-B | Preparation method of famotidine calcium and magnesium chewable tablets and products thereof | 西南药业股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104971073-B | Preparation method of famotidine calcium and magnesium chewable tablets and products thereof | 西南药业股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104906128-B | Compound famotidine calcium and magnesium chewable tablets and preparation method | 烟台荣昌制药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-104906128-B | Compound famotidine calcium and magnesium chewable tablets and preparation method | 烟台荣昌制药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-104906128-B | Compound famotidine calcium and magnesium chewable tablets and preparation method | 烟台荣昌制药股份有限公司 | 2017-08-11 | — | — | CN | disclosed |
| CN-104095875-B | Famotidine calcium and magnesium chewable tablet | 烟台荣昌制药股份有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-104095875-B | Famotidine calcium and magnesium chewable tablet | 烟台荣昌制药股份有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-104095875-B | Famotidine calcium and magnesium chewable tablet | 烟台荣昌制药股份有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-104906057-A | Preparation method for famotidine calcium and magnesium pellet type chewable tablets and products | XINAN PHARMACEUTICAL CO LTD | 2015-09-16 | — | — | CN | disclosed |
| CN-104906057-A | Preparation method for famotidine calcium and magnesium pellet type chewable tablets and products | XINAN PHARMACEUTICAL CO LTD | 2015-09-16 | — | — | CN | disclosed |