Famotidine

Famotidine

SCHEMBL458654

NC(N)=Nc1nc(CSCC/C(N)=N\S(N)(=O)=O)cs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH2

The experimentally established mechanism targets of Famotidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 known ✓ P25021 3/20 1.00
SLC22A2 O15244 2/20 1.00
CA12 O43570 2/20 1.00
SLC22A3 O75751 2/20 1.00
CA1 P00915 2/20 1.00
CA2 P00918 2/20 1.00
LMNA P02545 2/20 1.00
TSHR P16473 2/20 1.00
MAOA P21397 2/20 1.00
CA4 P22748 2/20 1.00
CA6 P23280 2/20 1.00
CA5A P35218 2/20 1.00
CA7 P43166 2/20 1.00
BLM P54132 2/20 1.00
PMP22 Q01453 2/20 1.00
POU5F1 Q01860 2/20 1.00
CA9 Q16790 2/20 1.00
SLC47A2 Q86VL8 2/20 1.00
CA13 Q8N1Q1 2/20 1.00
SLC47A1 Q96FL8 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Famotidine SCHEMBL39237 1.00 HRH2 (1.00) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL29384901 1.00 HRH2 (1.00) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL973 1.00 HRH2 (1.00) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL28032679 0.99 HRH2 (0.98) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL1863201 0.99 HRH2 (0.98) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL22127098 0.99 HRH2 (0.98) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL1863206 0.98 HRH2 (0.95) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL7119657 0.98 HRH2 (0.95) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL28528271 0.98 HRH2 (0.95) HRH2SLC22A2CA12SLC22A3CA1
Famotidine SCHEMBL9817308 0.98 HRH2 (0.95) HRH2SLC22A2CA12SLC22A3CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026043901-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING ENTEROVIRUSES WITH VAPENDAVIR SULFATE Altesa BioSciences, Inc. (US) 2026-02-26 WO claimed
US-20260048050-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING ENTEROVIRUSES WITH VAPENDAVIR SULFATE Altesa BioSciences, Inc. (US) 2026-02-19 US claimed
CN-118853094-A Environment-friendly single-phase immersed cooling liquid with vegetable oil as base oil and preparation method thereof 武汉泽电新材料有限公司 2024-10-29 CN claimed
WO-2021183259-A1 FAMOTIDINE AND FAMOTIDINE ANALOGS FOR CORONA VIRUS TREATMENT Nanopharmaceutics, Inc. (US) 2021-09-16 WO claimed
US-20260131089-A1 DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY APTARGROUP, INC. (US) 2026-05-14 US disclosed
US-20260132109-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2026-05-14 US disclosed
WO-2026043901-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING ENTEROVIRUSES WITH VAPENDAVIR SULFATE Altesa BioSciences, Inc. (US) 2026-02-26 WO disclosed
US-20260053745-A1 METHODS OF PROPHYLAXIS OF CORONAVIRUS INFECTION AND TREATMENT OF CORONAVIRUSES CUREMARK LLC (US) 2026-02-26 US disclosed
US-20260048050-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING ENTEROVIRUSES WITH VAPENDAVIR SULFATE Altesa BioSciences, Inc. (US) 2026-02-19 US disclosed
US-12503436-B2 Compounds and compositions for treating conditions associated with STING activity NOVARTIS PHARMA AG (CH) 2025-12-23 US disclosed
US-12491325-B2 Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization for treatment of binge-eating disorders and/or obesity APTARGROUP, INC. (US) 2025-12-09 US disclosed
US-12485094-B2 Methods of prophylaxis of coronavirus infection and treatment of coronaviruses CUREMARK, LLC (US) 2025-12-02 US disclosed
US-20090306228-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS SHIRE LLC (US) 2009-12-10 US disclosed
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS SHIRE LLC (US) 2009-10-08 US disclosed
US-20090137645-A1 Shelf-Stable Famotidine Granulates for Oral Suspensions MIDLOTHIAN LABORATORIES, LLC (US) 2009-05-28 US disclosed
US-20040156903-A1 Metering and packaging of controlled release medication MICRODOSE THERAPEUTX, INC. 2004-08-12 US disclosed
WO-1998040367-A1 NOVEL THIAZOLE DERIVATIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 1998-09-17 WO disclosed
EP-0707492-A1 H 2? ANTAGONIST-GASTROINTESTINAL MOTILITY AGENT COMBINATIONS MERCK & CO. INC. (US) 1996-04-24 EP disclosed
WO-1995001784-A1 H2 ANTAGONIST-SUCRALFATE-ANTIFLATULENT COMBINATIONS MERCK & CO., INC. (US) 1995-01-19 WO disclosed
WO-1995001803-A1 H2 ANTAGONIST-GASTROINTESTINAL MOTILITY AGENT COMBINATIONS MERCK & CO., INC. (US) 1995-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260131089-A1 DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY CACNG6, MC5R, CRH HRH2 2084/4885SLC22A2 2282/4885CA12 1418/4885
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS HDGF, CTSA, IAPP HRH2 3539/4885SLC22A2 776/4885CA12 282/4885
US-20260132109-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, IRF3, CGAS HRH2 638/4885SLC22A2 3440/4885CA12 4339/4885
US-20090306228-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS HDGF, CTSA, IAPP HRH2 3539/4885SLC22A2 776/4885CA12 282/4885
US-20260053745-A1 METHODS OF PROPHYLAXIS OF CORONAVIRUS INFECTION AND TREATMENT OF CORONAVIRUSES PRSS2, SPINT2, PRSS1 HRH2 2286/4885SLC22A2 2092/4885CA12 784/4885
US-20090137645-A1 Shelf-Stable Famotidine Granulates for Oral Suspensions KIT, GCGR, GCG HRH2 7/4885SLC22A2 1860/4885CA12 4649/4885
US-12503436-B2 Compounds and compositions for treating conditions associated with STING activity STING1, CGAS, IRF3 HRH2 875/4885SLC22A2 3570/4885CA12 4119/4885
US-20260048050-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING ENTEROVIRUSES WITH VAPENDAVIR SULFATE RPP30, EXOSC9, RPL30 HRH2 1570/4885SLC22A2 1077/4885CA12 3849/4885
US-12491325-B2 Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization for treatment of binge-eating disorders and/or obesity GCG, VAPA, GABRG2 HRH2 2029/4885SLC22A2 2161/4885CA12 2008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.