Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Famotidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 3/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 2/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | SLC22A3 | O75751 | 2/20 | 1.00 |
| ▸ | CA1 | P00915 | 2/20 | 1.00 |
| ▸ | CA2 | P00918 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | MAOA | P21397 | 2/20 | 1.00 |
| ▸ | CA4 | P22748 | 2/20 | 1.00 |
| ▸ | CA6 | P23280 | 2/20 | 1.00 |
| ▸ | CA5A | P35218 | 2/20 | 1.00 |
| ▸ | CA7 | P43166 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | POU5F1 | Q01860 | 2/20 | 1.00 |
| ▸ | CA9 | Q16790 | 2/20 | 1.00 |
| ▸ | SLC47A2 | Q86VL8 | 2/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 1.00 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Famotidine SCHEMBL29384901 | 1.00 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL458654 | 1.00 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL973 | 1.00 | HRH2 (1.00) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL28032679 | 0.99 | HRH2 (0.98) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL1863201 | 0.99 | HRH2 (0.98) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL22127098 | 0.99 | HRH2 (0.98) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL1863206 | 0.98 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL7119657 | 0.98 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL28528271 | 0.98 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 | |
| Famotidine SCHEMBL9817308 | 0.98 | HRH2 (0.95) | HRH2SLC22A2CA12SLC22A3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7561 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228644-B1 | N-[4-[1-(1,4-DIOXASPIRO[4.5]DEC-8-YL)-4-(8-OXA-3-AZABICYCLO[3.2.1]OCT-3-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL]PHENYL]-N'-METHYLUREA FOR USE IN THE TREATMENT OF COVID19 | NANTCELL INC (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4705072-A2 | METHOD AND DEVICE (SYSTEM) FOR PRODUCING A MATERIAL PANEL, MATERIAL PANEL, AND USE OF A MATERIAL PANEL | Siempelkamp Maschinen- und Anlagenbau GmbH (DE) | 2026-03-11 | — | — | EP | claimed |
| EP-4406605-B1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING AND PREVENTING ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH VIRAL INFECTIONS | HISTA RX LLC (US) | 2026-02-04 | — | — | EP | claimed |
| EP-4677066-A1 | NOVEL COMPOSITIONS AND THEIR USE TO INCREASE MOTILITY, VIABILITY AND LIFESPAN OF SPERM CELLS AND FERTILITY | IMV Technologies (FR) | 2026-01-14 | — | — | EP | claimed |
| EP-4037681-B1 | GEL-CHEWABLE DOSAGE FORM | KENVUE BRANDS LLC (US) | 2026-01-07 | — | — | EP | claimed |
| WO-2025245227-A1 | BACTERIAL CELL WALL COMPONENTS AS PROBES FOR A LABEL-FREE BINDING ASSAY AND THE USE THEREOF | ACADEMIA SINICA (TW) | 2025-11-27 | — | — | WO | claimed |
| WO-2025130078-A1 | UPLINK AND DOWNLINK SCHEDULING FOR WIRELESS COMMUNICATION SYSTEMS | ZTE CORPORATION (CN) | 2025-06-26 | — | — | WO | claimed |
| CN-120123621-A | Reservoir water temperature estimation method, system and storage medium | 国能大渡河瀑布沟发电有限公司 | 2025-06-10 | — | — | CN | claimed |
| CN-120034083-A | Work machine, heat radiation method thereof, heat radiation system and storage medium | 中联重科土方机械有限公司 | 2025-05-23 | — | — | CN | claimed |
| EP-3793518-B1 | AN ORAL TABLET FOR TASTE MASKING OF ACTIVE INGREDIENTS COMPRISING NON-DIRECTLY COMPRESSIBLE SUGAR ALCOHOL PARTICLES | FERTIN PHARMA AS (DK) | 2025-03-26 | — | — | EP | claimed |
| US-4481609-A | Semiconductor memory miniaturized by line groups and staggered cells | FUJITSU LIMITED (JP) | 1984-11-06 | — | — | US | claimed |
| EP-0098079-A2 | Semiconductor memory device with redundancy decoder circuit | FUJITSU LIMITED (JP) | 1984-01-11 | — | — | EP | claimed |
| EP-0072763-A2 | Semiconductor memory device | FUJITSU LIMITED (JP) | 1983-02-23 | — | — | EP | claimed |
| US-4314360-A | Semiconductor memory device | HIGUCHI MITSUO | 1982-02-02 | — | — | US | claimed |
| US-4300224-A | Electronic timepiece | KABUSHIKI KAISHA SUWA SEIKOSHA (JP) | 1981-11-10 | — | — | US | claimed |
| US-4258310-A | Selectively adjustable voltage detection integrated circuit | KABUSHIKI KAISHA SUWA SEIKOSHA (JP) | 1981-03-24 | — | — | US | claimed |
| US-4242679-A | Liquid crystal display mechanism | KABUSHIKI KAISHA SUWA SEIKOSHA (JP) | 1980-12-30 | — | — | US | claimed |
| US-4092524-A | Systems for storing and transferring data | SOCIETE INTERNATIONALE POUR L'INNOVATION (FR) | 1978-05-30 | — | — | US | claimed |
| US-4051354-A | FAULT-TOLERANT CELL ADDRESSABLE ARRAY | TEXAS INSTRUMENTS INCORPORATED (US) | 1977-09-27 | — | — | US | claimed |
| US-4047163-A | Fault-tolerant cell addressable array | TEXAS INSTRUMENTS INCORPORATED (US) | 1977-09-06 | — | — | US | claimed |