Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860465 | 0.80 | — | — | |
| SCHEMBL23829629 | 0.80 | — | — | |
| Proline SCHEMBL16394427 | 0.78 | BLM (0.48) | DPP4MEN1BLMKMT2ADPP8 | |
| Ammonia Solution, Strong SCHEMBL15875941 | 0.78 | — | — | |
| Proline SCHEMBL10141185 | 0.78 | — | — | |
| Proline SCHEMBL462226 | 0.78 | BLM (0.52) | DPP4MEN1BLMKMT2ADPP8 | |
| Proline SCHEMBL10141181 | 0.78 | — | — | |
| Proline SCHEMBL718906 | 0.78 | BLM (0.52) | DPP4MEN1BLMKMT2ADPP8 | |
| D-Proline SCHEMBL21462052 | 0.78 | BLM (0.52) | DPP4MEN1BLMKMT2ADPP8 | |
| Proline SCHEMBL2939 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106982599-A | A kind of method for delaying potato wedge root post-harvest physiology rotten | 中国科学院上海生命科学研究院 | 2017-07-28 | — | — | CN | disclosed |
| CN-102264697-B | Biosynthetically generated pyrroline-carboxy-lysine and site-specific protein modification by chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues | IRM LLC (BM) | 2015-09-09 | — | — | CN | disclosed |