Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.43 |
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066257 | 0.86 | PTGES (0.54) | PTGESPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2803916 | 0.85 | PTGES (0.51) | PTGESPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2802046 | 0.83 | PTGES (0.62) | PTGESPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2803278 | 0.82 | PTGES (0.61) | PTGESPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2802679 | 0.82 | PTGES (0.48) | PTGESKAT6ACYSLTR2CYSLTR1 | |
| SCHEMBL2802184 | 0.82 | PTGES (0.51) | PTGESKAT6A | |
| SCHEMBL2805238 | 0.82 | PTGES (0.48) | PTGES | |
| SCHEMBL2802125 | 0.82 | PTGES (0.51) | PTGESKAT6ACYSLTR2CYSLTR1 | |
| SCHEMBL978258 | 0.81 | PTGES (0.52) | PTGESCYSLTR2CYSLTR1 | |
| SCHEMBL978260 | 0.81 | PTGES (0.64) | PTGESCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292279-A1 | Bis-(Sulfonylamino) Derivatives in Therapy | PTGER1, SULT2A1, SULT1E1 | PTGES 9/4885PDE4B 1521/4885PDE4A 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.