SCHEMBL28033797

SCHEMBL28033797

O=C(Nc1ccc(O)cc1)c1ccc(C2CC2)cc1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DEGS1 O15121 1/20 0.53
SNCA P37840 3/20 0.49
KMT2A Q03164 3/20 0.47
LMNA P02545 3/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
ALDH1A1 P00352 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
GAA P10253 1/20 0.47
HDAC3 O15379 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
MEN1 O00255 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 2/20 0.45
NQO2 P16083 1/20 0.43
POLB P06746 1/20 0.42
GFER P55789 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16759726 0.87 KMT2A (0.52) KMT2ALMNANPC1RAB9AALDH1A1
SCHEMBL28033796 0.86 DEGS1 (0.56) DEGS1SNCALMNAHDAC3HDAC11
SCHEMBL28033800 0.83 DEGS1 (0.52) DEGS1SNCALMNANPC1RAB9A
SCHEMBL13544729 0.80 NPC1 (0.66) NPC1RAB9AALDH1A1SMN1; SMN2MAPT
SCHEMBL25981362 0.79 CA1 (0.46) SNCAKMT2ALMNANPC1RAB9A
SCHEMBL29924409 0.76 MAOB (0.41)
SCHEMBL17669255 0.76 MAOB (0.41)
SCHEMBL13544730 0.75 NPC1 (0.47) NPC1RAB9AALDH1A1SMN1; SMN2MAPT
SCHEMBL28034400 0.74 SNCA (0.51) DEGS1SNCAKMT2ALMNANPC1
SCHEMBL10148375 0.74 ACMSD (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250154211-A1 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2025-05-15 US disclosed
US-20240218027-A1 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2024-07-04 US disclosed
US-11834479-B2 Nucleoside triphosphate transporter and uses thereof THE SCRIPPS RESEARCH INSTITUTE (US) 2023-12-05 US disclosed
EP-4163293-A1 NOVEL NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF The Scripps Research Institute (US) 2023-04-12 EP disclosed
EP-3475295-B1 NOVEL NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF SCRIPPS RESEARCH INST (US) 2022-08-10 EP disclosed
CN-105085433-B Substituted amide phenol compound and preparation method thereof, pharmaceutical composition and purposes 中国科学院上海药物研究所 2019-06-25 CN disclosed
CN-105085433-A Substituted-amide phenolic compound, preparation method, pharmaceutical composition and application thereof SHANGHAI INST MATERIA MEDICA 2015-11-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154211-A1 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF SLC35B2, SLC29A2, PNP DEGS1 2925/4885SNCA 4445/4885KMT2A 3588/4885
US-20240218027-A1 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF SLC35B2, SLC29A2, PNP DEGS1 2925/4885SNCA 4445/4885KMT2A 3588/4885
US-11834479-B2 Nucleoside triphosphate transporter and uses thereof SLC35B2, SLC29A2, PNP DEGS1 2925/4885SNCA 4445/4885KMT2A 3588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.