Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 4/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033797 | 0.86 | DEGS1 (0.53) | DEGS1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL2270561 | 0.81 | LMNA (0.68) | DEGS1LMNAALOX15NQO2KLKB1 | |
| SCHEMBL28822507 | 0.74 | ACMSD (0.64) | KLKB1 | |
| SCHEMBL28033800 | 0.73 | DEGS1 (0.52) | DEGS1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL19013936 | 0.73 | HDAC8 (0.57) | DEGS1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL4963284 | 0.72 | DEGS1 (0.58) | DEGS1LMNAALOX15HDAC3HDAC11 | |
| SCHEMBL16759726 | 0.72 | KMT2A (0.52) | LMNA | |
| SCHEMBL8438123 | 0.72 | NPC1 (0.66) | LMNAALOX15KLKB1PLGKLK1 | |
| SCHEMBL16055426 | 0.72 | CA12 (0.59) | LMNA | |
| SCHEMBL20284041 | 0.72 | DEGS1 (1.00) | DEGS1HDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085433-B | Substituted amide phenol compound and preparation method thereof, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2019-06-25 | — | — | CN | disclosed |
| CN-105085433-A | Substituted-amide phenolic compound, preparation method, pharmaceutical composition and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-11-25 | — | — | CN | disclosed |