Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033626 | 0.87 | POLB (0.47) | POLBMAPK1ALDH1A1GPR139MAPT | |
| SCHEMBL28034185 | 0.85 | ALDH1A1 (0.48) | POLBMAPK1ALDH1A1MAPTTDP1 | |
| SCHEMBL23000166 | 0.80 | MTOR (0.60) | MAPK1GPR139MTORMEN1KMT2A | |
| SCHEMBL15664050 | 0.80 | ALDH1A1 (0.51) | PGRARALDH1A1MTORMEN1 | |
| SCHEMBL3861418 | 0.78 | HTT (0.56) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3861412 | 0.78 | HTT (0.56) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL22836032 | 0.78 | HTT (0.56) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| Nitrobenzene SCHEMBL30072248 | 0.78 | ALDH1A1 (0.61) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6338253 | 0.78 | TDP1 (0.58) | POLBMAPK1ALDH1A1MAPTTDP1 | |
| SCHEMBL31546661 | 0.75 | KMT2A (0.51) | PGRARMAPK1ALDH1A1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104981247-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2015-10-14 | — | — | CN | disclosed |