Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | RARB | P10826 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27489635 | 0.99 | HSD17B10 (0.37) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27489633 | 0.96 | HSD11B1 (0.35) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27689381 | 0.93 | HSD17B10 (0.38) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27446170 | 0.92 | HSD17B10 (0.37) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27462651 | 0.92 | HSD17B10 (0.37) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27689398 | 0.92 | HSD17B10 (0.37) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27463585 | 0.91 | EDNRB (0.32) | — | |
| Hydrochloric Acid SCHEMBL27464021 | 0.90 | HSD11B1 (0.35) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27670344 | 0.89 | HSD17B10 (0.35) | HSD11B1RARBHSD17B10TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27689388 | 0.89 | SLC6A2 (0.33) | HSD11B1RARBHSD17B10TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103012623-B | Metalloscene catalyst, its synthesis and purposes in olefin polymerization | NOVOLEN TECH HOLDINGS CV (DE) | 2015-09-16 | — | — | CN | disclosed |