Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172354 | 0.77 | ALDH1A1 (0.56) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL2596089 | 0.77 | TDP1 (0.63) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL30511098 | 0.77 | TDP1 (0.63) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL28643528 | 0.76 | ALDH1A1 (0.54) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL538054 | 0.76 | ALDH1A1 (0.54) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL31047153 | 0.76 | ALDH1A1 (0.54) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL16535036 | 0.74 | TDP1 (0.59) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL4161475 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL538070 | 0.74 | KMT2A (0.55) | TDP1ALDH1A1HPGDGLAMAPT | |
| SCHEMBL358560 | 0.74 | TDP1 (0.59) | TDP1ALDH1A1HPGDGLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157297-A | PRMT5 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-105102453-B | benzimidazolone derivatives as bromodomain inhibitors | 吉利德科学公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-105102453-A | Benzimidazolone derivatives as bromodomain inhibitors | GILEAD SCIENCES INC | 2015-11-25 | — | — | CN | disclosed |