Sugi Predict

Sugi Predict / Compounds / SCHEMBL358560

SCHEMBL358560

SCHEMBL358560

Nc1cc2ccccc2nc1Br

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.59
▸ ALDH1A1 P00352 5/20 0.52
▸ MAPT P10636 4/20 0.52
▸ HPGD P15428 3/20 0.52
▸ GLA P06280 2/20 0.52
▸ ACHE P22303 1/20 0.52
▸ GAA P10253 4/20 0.52
▸ KDM4E B2RXH2 4/20 0.52
▸ KMT2A Q03164 4/20 0.52
▸ NPC1 O15118 4/20 0.52
▸ RAB9A P51151 3/20 0.52
▸ POLB P06746 2/20 0.52
▸ LMNA P02545 1/20 0.52
▸ PTBP1 P26599 1/20 0.52
▸ RCE1 Q9Y256 1/20 0.52
▸ HTR3A P46098 1/20 0.48
▸ MEN1 O00255 2/20 0.46
▸ USP2 O75604 1/20 0.46
▸ CACNA1B Q00975 1/20 0.46
▸ APBA1 Q02410 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL359102 0.77 TLR8 (0.57) ALDH1A1MAPTHPGDGLAACHE
SCHEMBL29454362 0.77 TLR8 (0.57) ALDH1A1MAPTHPGDGLAACHE
SCHEMBL2596089 0.77 TDP1 (0.63) TDP1ALDH1A1MAPTHPGDGLA
SCHEMBL30511098 0.77 TDP1 (0.63) TDP1ALDH1A1MAPTHPGDGLA
Hydrochloric Acid SCHEMBL27365120 0.76 TLR8 (0.55) ALDH1A1MAPTHPGDGLAACHE
Acridine SCHEMBL10827474 0.75 ALDH1A1 (0.75) TDP1ALDH1A1MAPTHPGDGLA
SCHEMBL8788171 0.74 ALDH1A1 (0.52) ALDH1A1MAPTHPGDGLAACHE
SCHEMBL1721458 0.74 ALDH1A1 (0.52) TDP1ALDH1A1MAPTHPGDGLA
SCHEMBL1133368 0.74 ALDH1A1 (0.52) ALDH1A1MAPTHPGDGLAACHE
SCHEMBL949288 0.74 ALDH1A1 (0.59) TDP1ALDH1A1MAPTHPGDGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-05-29 — — US disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 — — US disclosed
CN-119823186-A Doped material in light-emitting layer of organic electroluminescent device and device 吉林奥来德光电材料股份有限公司 2025-04-15 — — CN disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 — — US disclosed
WO-2025030163-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE HORIZON THERAPEUTICS IRELAND DAC (IE) 2025-02-06 — — WO disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 — — US disclosed
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-04-09 — — US disclosed
EP-3687543-B1 COMBINATIONS OF PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-03-20 — — EP disclosed
CN-116745298-A Novel compound and organic light emitting device comprising the same 株式会社LG化学 2023-09-12 — — CN disclosed
CN-111386118-B Combination pharmaceutical agents as RSV inhibitors 英安塔制药有限公司 2023-05-09 — — CN disclosed
EP-3324977-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS Enanta Pharmaceuticals, Inc. (US) 2018-05-30 — — EP disclosed
US-9957281-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2018-05-01 — — US disclosed
CN-107573950-A A kind of aligning agent for liquid crystal, liquid crystal orientation film and liquid crystal display cells 中节能万润股份有限公司 2018-01-12 — — CN disclosed
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2017-01-26 — — US disclosed
WO-2017015449-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2017-01-26 — — WO disclosed
EP-2593107-A1 TYROSINE KINASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2013-05-22 — — EP disclosed
EP-2323661-B1 A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS UNIV LEIDEN (NL) 2013-04-17 — — EP disclosed
WO-2012009194-A1 TYROSINE KINASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-01-19 — — WO disclosed
CN-102123709-A A3Adenosine receptor allosteric modulators UNIV LEIDEN 2011-07-13 — — CN disclosed
US-20110144156-A1 A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS UNIVERSITEIT LEIDEN (NL) 2011-06-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 TDP1 3446/4885ALDH1A1 621/4885MAPT 2157/4885
US-20110144156-A1 A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS ADORA3, ADORA2A, ADORA1 TDP1 2296/4885ALDH1A1 2719/4885MAPT 4299/4885
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 TDP1 3446/4885ALDH1A1 621/4885MAPT 2157/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 TDP1 3446/4885ALDH1A1 621/4885MAPT 2157/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 TDP1 4684/4885ALDH1A1 4172/4885MAPT 2865/4885
US-20170022221-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 TDP1 3446/4885ALDH1A1 621/4885MAPT 2157/4885
US-20250171431-A1 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE IGF1R, TRHR, TSHR TDP1 806/4885ALDH1A1 1694/4885MAPT 3496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.