Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211006 | 0.83 | PDE3B (0.49) | PGR | |
| SCHEMBL10714214 | 0.77 | PGR (0.42) | PGRMAPTHDAC1HDAC6HTR7 | |
| SCHEMBL8210790 | 0.73 | MEN1 (0.39) | PGRMAPT | |
| SCHEMBL14438188 | 0.73 | NQO2 (0.50) | MAPT | |
| SCHEMBL3423085 | 0.70 | CA1 (0.41) | — | |
| SCHEMBL17260218 | 0.69 | GSK3B (0.49) | MAPT | |
| SCHEMBL2056415 | 0.69 | MAPT (0.42) | PGRMAPT | |
| SCHEMBL2054640 | 0.69 | MEN1 (0.42) | PGRMAPT | |
| SCHEMBL2056355 | 0.69 | SMN1; SMN2 (0.42) | PGRMAPT | |
| SCHEMBL20600322 | 0.67 | IDO1 (0.50) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102452-B | The ketones derivant of 5 (base of 3,5 dimethyl isoxazole 4) indoline 2 of substitution | 百济神州有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105102452-A | Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE LTD | 2015-11-25 | — | — | CN | disclosed |