Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28004213 | 0.80 | NPC1 (0.47) | PPARAPPARGPKM | |
| Bicarbonate SCHEMBL27541289 | 0.78 | KMT2A (0.68) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL15899527 | 0.77 | SLC6A2 (0.38) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL10448877 | 0.77 | KMT2A (0.56) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL8161607 | 0.77 | FOLH1 (0.45) | KMT2APPARAPPARGFOLH1 | |
| SCHEMBL8861750 | 0.77 | KMT2A (0.57) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL6493977 | 0.76 | KMT2A (0.51) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL10448750 | 0.76 | BRS3 (0.44) | PPARAPPARGSCN1ASCN2ASCN3A | |
| SCHEMBL15899526 | 0.75 | THRA (0.38) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL1839612 | 0.75 | HTR1A (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008407-B | Process for producing propylene block copolymer | 东邦钛株式会社 | 2018-03-06 | — | — | CN | disclosed |
| CN-105008407-A | Process for producing propylene block copolymer | TOHO TITANIUM CO LTD | 2015-10-28 | — | — | CN | disclosed |