Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28308438 | 0.97 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL516453 | 0.97 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16106188 | 0.95 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28248281 | 0.95 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL15993921 | 0.95 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL23355962 | 0.95 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28920946 | 0.92 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29218004 | 0.92 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29198765 | 0.92 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28273927 | 0.92 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117737449-A | Method for preparing metallic zinc by selectively leaching zinc calcine of zinc sulfide concentrate by using eutectic solvent | 东北大学 | 2024-03-22 | — | — | CN | claimed |
| CN-113943303-A | Clean synthesis of copper phthalocyanine in ethylene glycol-urea choline chloride mixed solvent | 河北科技大学 | 2022-01-18 | — | — | CN | claimed |
| CN-117737449-A | Method for preparing metallic zinc by selectively leaching zinc calcine of zinc sulfide concentrate by using eutectic solvent | 东北大学 | 2024-03-22 | — | — | CN | disclosed |
| CN-113943303-A | Clean synthesis of copper phthalocyanine in ethylene glycol-urea choline chloride mixed solvent | 河北科技大学 | 2022-01-18 | — | — | CN | disclosed |
| CN-113943303-A | Clean synthesis of copper phthalocyanine in ethylene glycol-urea choline chloride mixed solvent | 河北科技大学 | 2022-01-18 | — | — | CN | disclosed |
| CN-111826691-B | Method for preparing zinc-tantalum alloy by using solvated ionic liquid | 东北大学 | 2021-09-21 | — | — | CN | disclosed |
| CN-111826691-A | Method for preparing zinc-tantalum alloy by using solvated ionic liquid | 东北大学 | 2020-10-27 | — | — | CN | disclosed |
| CN-109267123-A | Choline chloride class ion liquid type electrolyte and preparation method for nickel-cobalt alloy plating | 沈阳理工大学 | 2019-01-25 | — | — | CN | disclosed |
| CN-105037062-A | Alcohol-based ternary deep-eutectic solvent and preparation method thereof | UNIV TIANJIN TECHNOLOGY | 2015-11-11 | — | — | CN | disclosed |