Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28308438 | 1.00 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16106188 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28036788 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL15993921 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28248281 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL23355962 | 0.97 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28920946 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29198765 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29218004 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28273927 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 824 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221983-A | High-strength multifunctional gelatin-based packaging film and preparation method thereof | 陕西科技大学 | 2024-06-21 | — | — | CN | claimed |
| CN-118166055-A | Crayfish shell ACE (angiotensin converting enzyme) inhibitory peptide and preparation method and application thereof | 湖北工业大学 | 2024-06-11 | — | — | CN | claimed |
| CN-115672278-B | Mecalcidone adsorbent and application thereof | 西南政法大学 | 2024-05-24 | — | — | CN | claimed |
| CN-118064527-A | Method for synthesizing ethyl rutin by using eutectic solvent catalysis | 皖南医学院 | 2024-05-24 | — | — | CN | claimed |
| CN-118064516-A | Method for improving aglycone conversion efficiency by using eutectic solvent | 皖南医学院 | 2024-05-24 | — | — | CN | claimed |
| CN-116144039-B | Method for separating natural lignin | 东北林业大学 | 2024-05-14 | — | — | CN | claimed |
| CN-117945383-A | Method for preparing carbon micro-tube by DES and ionic liquid | 广西大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117843831-A | Modified pectin for adsorbing heavy metals and preparation method thereof | 河北科技大学 | 2024-04-09 | — | — | CN | claimed |
| CN-117737449-A | Method for preparing metallic zinc by selectively leaching zinc calcine of zinc sulfide concentrate by using eutectic solvent | 东北大学 | 2024-03-22 | — | — | CN | claimed |
| CN-117737802-A | Bright ruthenium plating electroplating solution, preparation method and application | 东北大学 | 2024-03-22 | — | — | CN | claimed |
| CN-104607186-A | Multiwalled carbon nanotube-loaded PdSn catalyst based on deep eutectic solvent, and preparation method and application of catalyst | UNIV GUANGXI NORMAL | 2015-05-13 | — | — | CN | claimed |
| CN-104588046-A | Method for preparing BiOCl by using choline chloride/urea low-melting-point eutectic solvent as burning agent | UNIV LIAONING SHIHUA | 2015-05-06 | — | — | CN | claimed |
| CN-104370959-A | Preparation method of mesoporous cadmium hydroxyethylidene diphosphonate and preparation method of phosphonate-biological enzyme composite catalytic material | UNIV LUDONG | 2015-02-25 | — | — | CN | claimed |
| CN-104357526-A | Method for preparing cholestenone by using eutectic mixture as solubilization promoting agent through resting cell transformation | UNIV TIANJIN SCIENCE & TECH | 2015-02-18 | — | — | CN | claimed |
| US-8420732-B2 | Polybenzimidazole solution in an ionic liquid | PBI PERFORMANCE PRODUCTS, INC. (US) | 2013-04-16 | — | — | US | claimed |
| WO-2012087442-A1 | POLYBENZIMIDAZOLE SOLUTION IN AN IONIC LIQUID | PBI PERFORMANCE PRODUCTS, INC. (US) | 2012-06-28 | — | — | WO | claimed |
| US-20120142830-A1 | POLYBENZIMIDAZOLE SOLUTION IN AN IONIC LIQUID | DAWKINS BOBBY G (US) | 2012-06-07 | — | — | US | claimed |
| US-20120083433-A1 | Boron Containing Vegetable Oil Based Antiwear/Antifriction Additive and Their Preparation | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE | 2012-04-05 | — | — | US | claimed |
| WO-2012044681-A2 | BORON CONTAINING VEGETABLE OIL BASED ANTIWEAR/ANTIFRICTION ADDITIVE AND THEIR PREPARATION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2012-04-05 | — | — | WO | claimed |
| US-20110152413-A1 | POLYBENZIMIDAZOLE SOLUTION IN AN IONIC LIQUID | PBI PERFORMANCE PRODUCTS, INC. | 2011-06-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083433-A1 | Boron Containing Vegetable Oil Based Antiwear/Antifriction Additive and Their Preparation | FASN, ELOVL1, ELOVL3 | CYP3A4 1712/4885SLC5A7 4298/4885LMNA 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.