Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604523 | 0.84 | HRH4 (0.54) | KMT2AMEN1PRKCZKDM4EALDH1A1 | |
| SCHEMBL602336 | 0.81 | PRKCZ (0.51) | KMT2AMEN1PRKCZHRH4ADRB1 | |
| SCHEMBL605467 | 0.79 | DRD2 (0.64) | KMT2AMEN1PRKCZKDM4EALDH1A1 | |
| SCHEMBL10343427 | 0.79 | MEN1 (0.75) | KMT2AMEN1PRKCZKDM4EALDH1A1 | |
| SCHEMBL2804898 | 0.78 | HTT (0.43) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10325646 | 0.78 | MEN1 (0.73) | KMT2AMEN1PRKCZKDM4EALDH1A1 | |
| SCHEMBL15387694 | 0.75 | AKT1 (0.44) | PRKCZKDM4EALDH1A1LMNATSHR | |
| Trifluoroacetic Acid SCHEMBL9101425 | 0.73 | PRKCZ (0.44) | KMT2AMEN1PRKCZALDH1A1NPSR1 | |
| SCHEMBL4119266 | 0.71 | KIT (0.47) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL9883819 | 0.70 | HRH4 (0.47) | PRKCZHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |