Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.77 |
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 1.00 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Maleate SCHEMBL28037663 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL60132 | 1.00 | — | — | |
| Dimethyl Maleate SCHEMBL19690393 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL28468249 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL15573962 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL126468 | 1.00 | — | — | |
| Monomethyl Fumarate SCHEMBL25280962 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Dimethyl Fumarate SCHEMBL15573963 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| Monomethyl Fumarate SCHEMBL60133 | 1.00 | — | — | |
| Dimethyl Maleate SCHEMBL6896824 | 1.00 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105850-B | Waterborne polyurethane-acrylate-epoxidized soybean oil label adhesive and preparation method thereof | 华南理工大学 | 2022-07-12 | — | — | CN | claimed |
| EP-3990563-B1 | ACCELERATE CURE POLYURETHANE ADHESIVE COMPOSITION | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2026-03-18 | — | — | EP | disclosed |
| EP-3080185-B1 | IMPROVED POLYURETHANE PREPOLYMERS HAVING LITTLE OR NO PLASTICIZER AND THEIR USE IN VEHICULAR GLASS ADHESIVES | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2025-04-23 | — | — | EP | disclosed |
| US-12060452-B2 | Polyol compositions | PRESIDIUM USA, INC (US) | 2024-08-13 | — | — | US | disclosed |
| EP-3818090-B1 | PRIMERLESS POLYURETHANE ADHESIVE COMPOSITIONS | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20240010786-A9 | POLYOL COMPOSITIONS | PRESIDIUM INNOVATIONS, LLC | 2024-01-11 | — | — | US | disclosed |
| US-11859109-B2 | Primerless polyurethane adhesive compositions | DDP SPECIALTY ELECTRONIC MATERIALS US, LLC (US) | 2024-01-02 | — | — | US | disclosed |
| US-11732080-B2 | Compositions containing hydrophobic modified isocyanate functional prepolymer containing adhesives | DDP SPECIALTY ELECTRONICS MATERIALS US, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11718702-B2 | Adhesive useful for installing vehicle windows | DDP SPECIALTY ELECTRONIC MATERIALS US, LLC (US) | 2023-08-08 | — | — | US | disclosed |
| US-11426924-B2 | Thermoset additive manufactured articles incorporating a phase change material and method to make them | DOW GLOBAL TECHNOLOGIES LLC (US) | 2022-08-30 | — | — | US | disclosed |
| US-20220228045-A1 | ACCELERATE CURE POLYURETHANE ADHESIVE COMPOSITION | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2022-07-21 | — | — | US | disclosed |
| CN-113105850-B | Waterborne polyurethane-acrylate-epoxidized soybean oil label adhesive and preparation method thereof | 华南理工大学 | 2022-07-12 | — | — | CN | disclosed |
| CN-111902445-B | Adhesive useful for mounting vehicle windows | DDP特种电子材料美国公司 | 2022-06-17 | — | — | CN | disclosed |
| EP-2324071-B2 | IMPROVED PROCESS FOR BONDING REACTIVE ADHESIVES TO SUBSTRATES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2022-05-04 | — | — | EP | disclosed |
| EP-3990563-A1 | ACCELERATE CURE POLYURETHANE ADHESIVE COMPOSITION | DDP Specialty Electronic Materials US, LLC (US) | 2022-05-04 | — | — | EP | disclosed |
| EP-3746495-B1 | ADHESIVE USEFUL FOR INSTALLING VEHICLE WINDOWS | DDP SPECIALTY ELECTRONIC MATERIALS US LLC (US) | 2022-03-09 | — | — | EP | disclosed |
| CN-105126936-A | Method for preparing weakly acidic cation chromatographic column packing exchange resin | QINGDAO SHENGHAN CHROMATOGRAPHY TECHNOLOGY CO LTD | 2015-12-09 | — | — | CN | disclosed |