Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28771530 | 0.82 | CYP3A4 (0.43) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL28771528 | 0.82 | CYP3A4 (0.43) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL28841486 | 0.75 | MMP8 (0.54) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL28134677 | 0.75 | PTPN1 (0.50) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL7091384 | 0.75 | MMP8 (0.46) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL6054543 | 0.73 | MMP8 (0.45) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL28879399 | 0.73 | MMP8 (0.45) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL28800517 | 0.72 | MMP8 (0.44) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL5144292 | 0.72 | MMP8 (0.51) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL7882532 | 0.72 | MMP8 (0.44) | MMP8ALDH1A1CYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918928-A | Tricyclic compounds, their preparation and use | ZAFGEN INC | 2015-09-16 | — | — | CN | disclosed |