Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31036104 | 0.80 | ALDH1A1 (0.47) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL28038071 | 0.79 | ATAD2 (0.43) | POLBALDH1A1KMT2AGAAMAPT | |
| SCHEMBL27888908 | 0.76 | HTR2C (0.46) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL27660153 | 0.74 | SIRT2 (0.50) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL1867023 | 0.72 | MAPT (0.45) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL28016150 | 0.72 | ALDH1A1 (0.50) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL27975623 | 0.72 | SIRT2 (0.48) | SIRT2POLBAPEX1CASP6CTDSP1 | |
| SCHEMBL3885369 | 0.72 | SIRT2 (0.55) | SIRT2CASP6ALDH1A1LMNAKMT2A | |
| SCHEMBL29191130 | 0.72 | SIRT2 (0.51) | SIRT2ALDH1A1LMNAKMT2AHTR2C | |
| SCHEMBL3041124 | 0.70 | SIRT2 (0.63) | SIRT2POLBAPEX1CASP6CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104936944-A | Indole full ketone derivative used as tyrosine-kinase inhibitor | KBP BIOSCIENCES CO LTD | 2015-09-23 | — | — | CN | disclosed |