Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benoxaprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | CASP3 | P42574 | 5/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benoxaprofen SCHEMBL24413 | 0.99 | MAOA (1.00) | MAOAADRA1ACASP3SENP7HDAC3 | |
| Benoxaprofen SCHEMBL24414 | 0.99 | MAOA (1.00) | MAOAADRA1ACASP3SENP7HDAC3 | |
| Benoxaprofen SCHEMBL29364205 | 0.99 | MAOA (1.00) | MAOAADRA1ACASP3SENP7HDAC3 | |
| Benoxaprofen SCHEMBL11246423 | 0.98 | MAOA (0.98) | MAOAADRA1ACASP3SENP7HDAC3 | |
| SCHEMBL12608959 | 0.91 | MAOA (0.86) | MAOAADRA1ACASP3SENP7HDAC3 | |
| SCHEMBL3196762 | 0.89 | MAOA (0.82) | MAOAADRA1ACASP3SENP7HDAC3 | |
| SCHEMBL11176670 | 0.89 | MAOA (0.82) | MAOAADRA1ACASP3SENP7HDAC3 | |
| Benoxaprofen SCHEMBL6694507 | 0.88 | MAOA (0.80) | MAOAADRA1ACASP3SENP7HDAC6 | |
| SCHEMBL9706321 | 0.87 | MAOA (0.79) | MAOAADRA1ACASP3SENP7HDAC3 | |
| Benoxaprofen SCHEMBL7925364 | 0.87 | MAOA (0.77) | MAOAADRA1ACASP3SENP7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108135875-B | Methods and compositions for treating metabolic reprogramming disorders | 约翰霍普金斯大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-108348492-B | Methods for cancer and immunotherapy using glutamine analogs | 约翰霍普金斯大学 | 2021-09-28 | — | — | CN | disclosed |
| CN-112920092-A | Prodrugs of glutamine analogs | 约翰霍普金斯大学 | 2021-06-08 | — | — | CN | disclosed |
| CN-108290827-B | Prodrugs of glutamine analogs | 约翰霍普金斯大学 | 2021-01-01 | — | — | CN | disclosed |
| CN-111479574-A | Compounds for the treatment and prevention of extracellular histone mediated pathologies | 澳大利亚国立大学 | 2020-07-31 | — | — | CN | disclosed |
| CN-105025945-B | Drug delivery device for peripheral arterial disease | 艾博特心血管系统公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-105025945-A | Drug delivery device for peripheral arterial disease | ABBOTT CARDIOVASCULAR SYSTEMS | 2015-11-04 | — | — | CN | disclosed |