Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KYNU | Q16719 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473025 | 0.87 | MMP8 (0.55) | ALDH1A1CTSBTRPM8ALOX15MMP8 | |
| SCHEMBL139860 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL139859 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL27696619 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| Ammonia Solution, Strong SCHEMBL28148323 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| Hydrochloric Acid SCHEMBL4263027 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| Hydrochloric Acid SCHEMBL4263030 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL15177646 | 0.83 | HTT (0.49) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| Ammonia Solution, Strong SCHEMBL27854372 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL18082683 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KMT2AL3MBTL1MAPK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143212-B | Tripeptide epoxy ketone protease inhibitors | 欧尼斯治疗公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-105143212-A | Tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS INC | 2015-12-09 | — | — | CN | disclosed |