Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.37 |
| ▸ | ACLY | P53396 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27417452 | 0.86 | CNR2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27449972 | 0.83 | PTGER4 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27418241 | 0.83 | CYP19A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28746660 | 0.77 | RAB9A (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27430039 | 0.74 | KCNH2 (0.39) | PTGER4KCNH2 | |
| SCHEMBL27570408 | 0.70 | ALDH1A1 (0.37) | — | |
| SCHEMBL27919840 | 0.69 | CYP19A1 (0.46) | CYP19A1 | |
| SCHEMBL27633286 | 0.69 | MAPT (0.37) | CYP19A1 | |
| SCHEMBL27552395 | 0.68 | KCNA3 (0.33) | — | |
| SCHEMBL27782147 | 0.66 | EGFR (0.42) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105392787-A | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN LA ROCHE | 2016-03-09 | — | — | CN | disclosed |