Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290152 | 0.84 | TDP1 (0.49) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL8594489 | 0.84 | TDP1 (0.56) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL18421593 | 0.80 | TDP1 (0.52) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL30990566 | 0.79 | TDP1 (0.51) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL25181398 | 0.79 | TDP1 (0.50) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL12544235 | 0.78 | TDP1 (0.50) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL5147906 | 0.77 | TDP1 (0.49) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL23976920 | 0.77 | AOC1 (0.48) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL29923810 | 0.77 | TDP1 (0.49) | TDP1SIRT3KDM4CKDM4EALDH1A1 | |
| SCHEMBL3634352 | 0.77 | TDP1 (0.49) | TDP1SIRT3KDM4CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104981457-A | Heterocyclic compound | TAKEDA PHARMACEUTICAL | 2015-10-14 | — | — | CN | disclosed |