Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CES1 | P23141 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163311 | 0.81 | HPGD (0.61) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL9725428 | 0.80 | L3MBTL1 (0.77) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL82532 | 0.80 | L3MBTL1 (0.77) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL25423577 | 0.80 | L3MBTL1 (0.77) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL11522791 | 0.80 | L3MBTL1 (0.77) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| SCHEMBL28578487 | 0.79 | CES1 (0.63) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL28777877 | 0.79 | L3MBTL1 (0.59) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL27921458 | 0.78 | L3MBTL1 (0.74) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL11310788 | 0.78 | L3MBTL1 (0.74) | HPGDKMT2ACES1SMN1; SMN2MEN1 | |
| Butyrophenone SCHEMBL28260771 | 0.78 | L3MBTL1 (0.74) | HPGDKMT2ACES1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164125-A | 2-phenyl or 2-heteroaryl imidazo [1, 2-a ] pyridine derivatives | HOFFMANN LA ROCHE | 2015-12-16 | — | — | CN | disclosed |