SCHEMBL28039640

SCHEMBL28039640

[CH2]CNc1ccccc1-c1ccc(Br)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
MAPK1 P28482 2/20 0.40
PTPRC P08575 1/20 0.40
SLC6A3 Q01959 1/20 0.39
HPGD P15428 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ADRA2C P18825 2/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2B P18089 1/20 0.36
MAOA P21397 1/20 0.36
ADRA1D P25100 1/20 0.36
MAOB P27338 1/20 0.36
ADRA1A P35348 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.34
NPC1 O15118 2/20 0.34
MAPT P10636 2/20 0.34
TSHR P16473 2/20 0.34
RAB9A P51151 2/20 0.34
TP53 P04637 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28039342 0.84 ALDH1A1 (0.47) ALDH1A1HPGDKDM4EADRA2CADRA2A
SCHEMBL28039381 0.81 TDP1 (0.41) ALDH1A1SLC6A3HPGDKDM4EADRA2C
SCHEMBL28823485 0.81 QPCT (0.48) ALDH1A1SLC6A3HPGDKDM4EADRA2C
SCHEMBL28039358 0.77 ALDH1A1 (0.40) ALDH1A1MAPK1HPGDKDM4EMAOA
SCHEMBL11341407 0.76 ALDH1A1 (0.52) ALDH1A1SLC6A3HPGDKDM4EMAPT
Hydrochloric Acid SCHEMBL28946288 0.73 ALDH1A1 (0.43) ALDH1A1MAPK1PTPRCSLC6A3HPGD
SCHEMBL19125933 0.72 ALDH1A1 (0.63) ALDH1A1MAPK1PTPRCSLC6A3HPGD
SCHEMBL7522172 0.72 ALDH1A1 (0.63) ALDH1A1MAPK1PTPRCSLC6A3HPGD
SCHEMBL27686533 0.72 ALDH1A1 (0.46) ALDH1A1MAPK1SLC6A3HPGDKDM4E
SCHEMBL16694267 0.72 ALDH1A1 (0.46) ALDH1A1MAPK1PTPRCSLC6A3HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105017312-A Preparation method of beta-aminoethyl phosphono derivative UNIV SOOCHOW 2015-11-04 CN disclosed