SCHEMBL28039666

SCHEMBL28039666

NC(CO[PH](=O)OCC(N)c1ccc([N+](=O)[O-])cc1)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
IDO1 P14902 4/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
CA1 P00915 5/20 0.40
CA2 P00918 5/20 0.40
CA9 Q16790 4/20 0.40
CA12 O43570 3/20 0.40
CA14 Q9ULX7 3/20 0.40
MAPT P10636 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
PHLPP2 Q6ZVD8 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
GRM8 O00222 1/20 0.37
GRM6 O15303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28039667 0.88 ALDH1A1 (0.44) ALDH1A1IDO1LOXL2CA1CA2
SCHEMBL28945418 0.76 TSHR (0.46) ALDH1A1IDO1MAPTCYP1A2TSHR
SCHEMBL28039650 0.76 SCN4A (0.49) IDO1CYP1A2CYP3A4TSHRMAPK1
SCHEMBL28141975 0.75 SCN4A (0.55)
SCHEMBL942066 0.75 LOXL2 (0.53) ALDH1A1IDO1LOXL2CA1CA2
SCHEMBL18833848 0.75 LOXL2 (0.53) ALDH1A1IDO1LOXL2CA1CA2
Hydrochloric Acid SCHEMBL11740245 0.74 LOXL2 (0.52) ALDH1A1IDO1LOXL2CA1CA2
SCHEMBL894479 0.74 ALDH1A1 (0.49) ALDH1A1IDO1LOXL2CA1CA2
SCHEMBL895913 0.74 ALDH1A1 (0.49) ALDH1A1IDO1LOXL2CA1CA2
SCHEMBL6690598 0.74 LOXL2 (0.52) ALDH1A1IDO1LOXL2CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105017312-A Preparation method of beta-aminoethyl phosphono derivative UNIV SOOCHOW 2015-11-04 CN disclosed