Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28110914 | 0.73 | CYP11B1 (0.55) | ALDH1A1KDM4EMAPTCYP11B1CYP11B2 | |
| SCHEMBL6444709 | 0.70 | PCSK9 (0.73) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL28277444 | 0.70 | PCSK9 (0.45) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL8881198 | 0.70 | PCSK9 (0.45) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL16152323 | 0.70 | PCSK9 (0.45) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL9019096 | 0.70 | PCSK9 (0.45) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL28231026 | 0.70 | PCSK9 (0.45) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL2165710 | 0.68 | PCSK9 (0.44) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL347805 | 0.68 | PCSK9 (0.53) | PCSK9KDRMAP4K4PRKACACDK8 | |
| SCHEMBL15089192 | 0.67 | GLO1 (0.42) | KDRALDH1A1CYP1A2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008367-B | It is used as the pyrrolo-triazine class compound of potassium channel inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105008367-A | Pyrrolotriazines as potassium ion channel inhibitors | BRISTOL MYERS SQUIBB CO | 2015-10-28 | — | — | CN | disclosed |