Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11580515 | 0.79 | ALDH1A1 (0.38) | ALDH1A1PTPRCNPSR1CYP3A4CYP2D6 | |
| SCHEMBL30701070 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL17961787 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL28358593 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL13381564 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL15214378 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HSD17B10CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13044446 | 0.71 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22656819 | 0.70 | ALDH1A1 (0.40) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL11999087 | 0.69 | ALDH1A1 (0.39) | ALDH1A1HSD17B10POLBKDM4ELMNA | |
| SCHEMBL29441612 | 0.69 | ALDH1A1 (0.52) | ALDH1A1HSD17B10POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085407-A | Preparation method of Olaparib and analogue of Olaparib | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-105085408-A | Preparation method of Olaparib intermediate | GUANGZHOU YOUMIJIAN PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |