SCHEMBL28040306

SCHEMBL28040306

CC(=Nc1cccc(C)c1O[SiH](C)C)c1cnn(C)c1.[H+]

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.32
DHX9 Q08211 1/20 0.32
MAP3K5 Q99683 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499628 0.99 DHX9 (0.32) CHEK1DHX9MAP3K5MAPT
SCHEMBL16101780 0.85 DHX9 (0.34) DHX9MAP3K5MAPT
SCHEMBL28039922 0.85 ESR2 (0.39) CHEK1
SCHEMBL16101181 0.84 ESR2 (0.39) CHEK1
SCHEMBL17499588 0.83 DHX9 (0.33) DHX9MAP3K5MAPT
SCHEMBL28823594 0.81 DHX9 (0.32) CHEK1DHX9MAPT
SCHEMBL17499295 0.81 SMN1; SMN2 (0.34) DHX9MAPT
SCHEMBL16100011 0.80 DHX9 (0.32) DHX9MAP3K5MAPT
SCHEMBL17499261 0.78 ESR1 (0.30)
SCHEMBL28823563 0.77 MAPT (0.31) CHEK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105209268-A Heterocyclic imine functionalized polymers BRIDGESTONE CORP 2015-12-30 CN disclosed