SCHEMBL17499588

SCHEMBL17499588

CC(=Nc1cccc(C)c1O[Si](C)(C)C)c1cnn(C)c1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DHX9 Q08211 1/20 0.33
MAP3K5 Q99683 1/20 0.32
MAPT P10636 1/20 0.32
PROKR1 Q8TCW9 1/20 0.31
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16101780 0.88 DHX9 (0.34) DHX9MAP3K5MAPTPROKR1RAB9A
SCHEMBL16101494 0.85 ESR2 (0.37) PROKR1RAB9ASMN1; SMN2
SCHEMBL17499628 0.84 DHX9 (0.32) DHX9MAP3K5MAPTRAB9ASMN1; SMN2
SCHEMBL28040306 0.83 CHEK1 (0.32) DHX9MAP3K5MAPT
SCHEMBL17499412 0.81 SMN1; SMN2 (0.34) DHX9MAPTPROKR1RAB9ASMN1; SMN2
SCHEMBL17499749 0.81 DHX9 (0.33) DHX9MAP3K5MAPTPROKR1RAB9A
SCHEMBL16097361 0.78
SCHEMBL16097362 0.78
SCHEMBL17499227 0.77 MAPT (0.32) DHX9MAPTPROKR1
SCHEMBL17499354 0.76 MEN1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed