Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Propiophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CES1 | P23141 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propiophenone SCHEMBL318818 | 0.89 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL76464 | 0.89 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL14244535 | 0.89 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL9364510 | 0.87 | MAPT (0.67) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL3647864 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL8603451 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL28756649 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL7090411 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL30505634 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 | |
| Propiophenone SCHEMBL28024098 | 0.87 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2L3MBTL1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105087697-A | Method for roducing (S)-ethoxyl phenyl methanesulfonate by use of cells | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2015-11-25 | — | — | CN | claimed |
| CN-105087697-A | Method for roducing (S)-ethoxyl phenyl methanesulfonate by use of cells | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2015-11-25 | — | — | CN | disclosed |