SCHEMBL28041622

SCHEMBL28041622

C[C@H](NC(=O)Nc1ccc(Cl)cc1)c1ccc(F)cc1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 7/20 0.60
KMT2A Q03164 1/20 0.60
HSD17B10 Q99714 1/20 0.56
SLC6A3 Q01959 1/20 0.54
POLB P06746 1/20 0.54
RAB9A P51151 1/20 0.54
MTOR P42345 1/20 0.53
IDH1 O75874 1/20 0.50
ALDH1A1 P00352 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28041623 1.00 CNR1 (0.60) CNR1KMT2AHSD17B10SLC6A3POLB
SCHEMBL12994662 0.87 KMT2A (0.61) CNR1KMT2AHSD17B10RAB9AMTOR
SCHEMBL21793242 0.87 KMT2A (0.61) CNR1KMT2AHSD17B10RAB9AMTOR
SCHEMBL23718858 0.85 HSD17B10 (0.79) CNR1KMT2AHSD17B10POLBRAB9A
SCHEMBL23199937 0.85 HSD17B10 (0.79) CNR1KMT2AHSD17B10POLBRAB9A
SCHEMBL13182417 0.82 CNR1 (0.56) CNR1KMT2AHSD17B10RAB9AIDH1
SCHEMBL2408891 0.82 KMT2A (0.56) CNR1KMT2AHSD17B10RAB9AMTOR
SCHEMBL6374146 0.81 CNR1 (0.59) CNR1KMT2ASLC6A3POLBRAB9A
SCHEMBL6374689 0.81 CNR1 (0.59) CNR1KMT2ASLC6A3POLBRAB9A
SCHEMBL17119070 0.81 RAB9A (0.70) CNR1KMT2APOLBRAB9AIDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105237440-A Novel CRAC channel conditioning agent, and preparation method and applications thereof SHANGHAI INST MATERIA MEDICA 2016-01-13 CN disclosed