Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.79 |
| ▸ | MTOR | P42345 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23199937 | 1.00 | HSD17B10 (0.79) | HSD17B10MTORNPC1KMT2AALDH1A1 | |
| SCHEMBL9306555 | 0.89 | HSD17B10 (1.00) | HSD17B10MTORKMT2AALDH1A1CYP2C9 | |
| SCHEMBL9306563 | 0.89 | HSD17B10 (1.00) | HSD17B10MTORKMT2AALDH1A1CYP2C9 | |
| SCHEMBL12994662 | 0.86 | KMT2A (0.61) | HSD17B10MTORNPC1KMT2AMEN1 | |
| SCHEMBL21793242 | 0.86 | KMT2A (0.61) | HSD17B10MTORNPC1KMT2AALDH1A1 | |
| SCHEMBL28041623 | 0.85 | CNR1 (0.60) | HSD17B10MTORKMT2AALDH1A1CNR1 | |
| SCHEMBL28041622 | 0.85 | CNR1 (0.60) | HSD17B10MTORKMT2AALDH1A1CNR1 | |
| SCHEMBL16942608 | 0.83 | HSD17B10 (0.81) | HSD17B10MTORNPC1KMT2ACYP2C9 | |
| SCHEMBL16942602 | 0.83 | HSD17B10 (0.81) | HSD17B10MTORNPC1KMT2ACYP2C9 | |
| SCHEMBL2408891 | 0.81 | KMT2A (0.56) | HSD17B10MTORNPC1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | TPH1, KYNU, TPH2 | HSD17B10 972/4885MTOR 283/4885NPC1 3173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.