Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.61 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | PLG | P00747 | 2/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513105 | 0.84 | HTR3E (0.58) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL7068774 | 0.83 | SIGMAR1 (0.57) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL6660622 | 0.80 | F2 (0.59) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL11771075 | 0.79 | F2 (0.71) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL11771072 | 0.79 | F2 (0.71) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL5187866 | 0.79 | POLB (0.47) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL28445306 | 0.79 | SIGMAR1 (0.60) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL5186996 | 0.77 | CYP3A4 (0.53) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL7427722 | 0.77 | SIGMAR1 (0.64) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B | |
| SCHEMBL8320910 | 0.76 | SIGMAR1 (0.83) | SIGMAR1CYP1A2CYP3A4GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3298875-B2 | — | — | 2002-07-08 | — | — | JP | claimed |
| EP-0517852-A4 | — | — | 1994-03-02 | — | — | EP | claimed |
| EP-0517852-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1992-12-16 | — | — | EP | claimed |
| WO-1991012797-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) | 1991-09-05 | — | — | WO | claimed |
| CN-115335362-A | Chiral guanidine and its salt, method for producing chiral guanidine and its salt and use of chiral guanidine and its salt for producing enantiomerically pure amino acids | 付瑞 | 2022-11-11 | — | — | CN | disclosed |
| EP-3658141-A1 | TREATING PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA - CD47 INTERACTION | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) | 2020-06-03 | — | — | EP | disclosed |
| CN-110337435-A | Barbituric acid derivatives comprising cation group and lipophilic group | 特罗姆瑟大学-挪威北极圈大学 | 2019-10-15 | — | — | CN | disclosed |
| WO-2019022600-A1 | TREATING PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA - CD47 INTERACTION | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis (NL) | 2019-01-31 | — | — | WO | disclosed |
| CN-103339109-B | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC | 2015-04-29 | — | — | CN | disclosed |
| US-9006323-B2 | Dispersion containing flame-resistant polymer, flame-resistant fiber, and carbon fiber | TORAY INDUSTRIES, INC. (JP) | 2015-04-14 | — | — | US | disclosed |
| CN-103339109-A | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC | 2013-10-02 | — | — | CN | disclosed |
| CN-101903462-B | Dispersion containing flame-resistant polymer, flame-resistant fiber, and carbon fiber | TORAY INDUSTRIES | 2012-12-12 | — | — | CN | disclosed |
| CN-1212255-A | Biphenylsulfonylcyanamides, method for the production thereof and use thereof as medicaments | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-03-31 | — | — | CN | disclosed |
| EP-0903339-A2 | Biphenylsulfonylcyanamides, process for their preparation and their use as medicaments | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-24 | — | — | EP | disclosed |
| EP-0855392-A2 | Five-membered heterocycles having biphenylsulphonyl substituents, processes for the preparation thereof, their use as medicaments or diagnostic agent and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-29 | — | — | EP | disclosed |
| CN-1188760-A | Benzidine-sulfuryl radical substitution pentatomic heterocycle, its preparation method, its medicinal and composition | HOECHST AG (DE) | 1998-07-29 | — | — | CN | disclosed |
| EP-0517852-A4 | — | — | 1994-03-02 | — | — | EP | disclosed |
| EP-0517852-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1992-12-16 | — | — | EP | disclosed |
| WO-1991012797-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) | 1991-09-05 | — | — | WO | disclosed |
| EP-0178952-A2 | Toner, charge-imparting material and composition containing positively chargeable compound | CANON KABUSHIKI KAISHA (JP) | 1986-04-23 | — | — | EP | disclosed |