Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27911601 | 1.00 | TSHR (0.46) | TSHRMAPK1KMT2AMEN1LMNA | |
| Succinic Acid SCHEMBL1986734 | 0.88 | TSHR (0.59) | TSHRMAPK1KMT2AMEN1LMNA | |
| Guanidine SCHEMBL339540 | 0.87 | MEN1 (0.38) | TSHRMAPK1KMT2AMEN1LMNA | |
| Triethylene Glycol SCHEMBL1815430 | 0.85 | MEN1 (0.61) | TSHRMAPK1KMT2AMEN1LMNA | |
| Succinic Acid SCHEMBL10943498 | 0.85 | TSHR (0.56) | TSHRMAPK1KMT2AMEN1LMNA | |
| Tetraethylene Glycol SCHEMBL15049107 | 0.85 | MEN1 (0.61) | TSHRMAPK1KMT2AMEN1LMNA | |
| Succinic Acid SCHEMBL15048963 | 0.83 | TSHR (0.53) | TSHRMAPK1KMT2AMEN1LMNA | |
| Tetraethylene Glycol SCHEMBL7996654 | 0.83 | MEN1 (0.58) | TSHRMAPK1KMT2AMEN1LMNA | |
| Di(Hydroxyethyl)Ether SCHEMBL29046519 | 0.83 | TSHR (0.34) | TSHRMAPK1KMT2AMEN1LMNA | |
| Succinic Acid SCHEMBL6236115 | 0.83 | TSHR (0.34) | TSHRMAPK1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105120834-A | Antioxidant compositions and methods of use thereof | NEOCUTIS SA | 2015-12-02 | — | — | CN | disclosed |