Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL23069600 | 0.89 | ALDH1A1 (0.55) | SNCAGAAALDH1A1PKMHTT | |
| Alcohol SCHEMBL282056 | 0.88 | SNCA (0.56) | SNCAGAAALDH1A1PKMHTT | |
| Bicarbonate SCHEMBL7292653 | 0.88 | SNCA (0.64) | SNCAALDH1A1HTTLMNAL3MBTL1 | |
| Oxalic Acid SCHEMBL8992177 | 0.86 | SNCA (0.62) | SNCAALDH1A1KDM4ELMNAMEN1 | |
| Acetoacetic Acid SCHEMBL11516540 | 0.86 | SNCA (0.55) | SNCAGAAALDH1A1PKMHTT | |
| SCHEMBL29857297 | 0.86 | SNCA (0.65) | SNCAALDH1A1PKMHTTLMNA | |
| SCHEMBL1556 | 0.86 | SNCA (0.65) | SNCAALDH1A1PKMHTTLMNA | |
| SCHEMBL29357423 | 0.86 | SNCA (0.65) | SNCAALDH1A1PKMHTTLMNA | |
| SCHEMBL304050 | 0.86 | SNCA (0.65) | SNCAALDH1A1PKMHTTLMNA | |
| Naphthalene SCHEMBL28216326 | 0.86 | SNCA (0.65) | SNCAALDH1A1PKMHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452245-A | Preparation method of [1,2,4] -triazolo [4,3-a ] pyridine | AMGEN INC | 2016-03-30 | — | — | CN | disclosed |