Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17625285 | 0.74 | MAPT (0.41) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL5468464 | 0.74 | MAPT (0.71) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL9378258 | 0.71 | NOS2 (0.44) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL26598692 | 0.71 | MAPT (0.39) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL1221544 | 0.69 | NOS2 (0.46) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL17581161 | 0.69 | MAPT (0.38) | MAPTTDP1KDM4EKMT2A | |
| SCHEMBL5285063 | 0.67 | USP2 (0.40) | MAPTTDP1CYP3A4BLMKDM4E | |
| SCHEMBL15912796 | 0.67 | MPO (0.45) | TDP1CYP3A4KDM4E | |
| SCHEMBL30665479 | 0.67 | MPO (0.45) | TDP1CYP3A4KDM4E | |
| SCHEMBL28246185 | 0.67 | RPS6KA5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |