Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135738 | 0.87 | HPGD (0.63) | HPGDALDH1A1THRBSMN1; SMN2POLB | |
| SCHEMBL28032381 | 0.83 | HPGD (0.57) | HPGDALDH1A1THRBSMN1; SMN2POLB | |
| SCHEMBL28042363 | 0.81 | HPGD (0.63) | HPGDALDH1A1SMN1; SMN2L3MBTL1GLA | |
| SCHEMBL14719339 | 0.81 | ALDH2 (0.58) | HPGDALDH1A1THRBSMN1; SMN2POLB | |
| SCHEMBL16135653 | 0.81 | HPGD (0.57) | HPGDALDH1A1THRBSMN1; SMN2POLB | |
| SCHEMBL11484059 | 0.78 | ALDH1A1 (0.53) | HPGDALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12808041 | 0.76 | MMP2 (0.60) | HPGDALDH1A1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL11491951 | 0.76 | RAB9A (0.54) | HPGDALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28084506 | 0.75 | ALDH1A1 (0.55) | HPGDALDH1A1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL28032441 | 0.75 | HPGD (0.53) | HPGDALDH1A1SMN1; SMN2POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870435-A | Aryl and heteroaryl fused lactams | PFIZER | 2015-08-26 | — | — | CN | disclosed |