Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.74 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.74 |
| ▸ | CDK1 | P06493 | 2/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.74 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.74 |
| ▸ | GSK3A | P49840 | 1/20 | 0.68 |
| ▸ | GSK3B | P49841 | 1/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.68 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.68 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31064954 | 0.85 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1778522 | 0.85 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL7925181 | 0.81 | ADORA2A (0.67) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL491031 | 0.81 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL14115572 | 0.80 | RIPK1 (0.61) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL31308715 | 0.80 | RIPK1 (0.66) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL19909349 | 0.79 | CCNB2 (0.55) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1778505 | 0.78 | RIPK1 (0.74) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL14115574 | 0.78 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL31065003 | 0.78 | RIPK1 (1.00) | RIPK1CCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105246890-A | Pyrrolo[2, 3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-01-13 | — | — | CN | disclosed |