Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731125 | 0.83 | LMNA (0.57) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL28285589 | 0.81 | LMNA (0.55) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL1284277 | 0.79 | LMNA (0.53) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL866289 | 0.79 | LMNA (0.53) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL10532645 | 0.79 | LMNA (0.53) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL28843557 | 0.78 | LMNA (0.52) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL24152469 | 0.76 | LMNA (0.50) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL1231766 | 0.76 | LMNA (0.55) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL7206798 | 0.76 | LMNA (0.50) | LMNAKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL2594237 | 0.75 | LMNA (0.64) | LMNAKMT2AMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110234638-A | Heteroaryl phenoxy benzamide KAPPA opiates ligand | 辉瑞大药厂 | 2019-09-13 | — | — | CN | disclosed |
| CN-108137596-A | 1,2- dihydro -3H- pyrrolo-es [1,2-c] imidazoles -3- ketone antimicrobial compounds being substituted | 爱杜西亚药品有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107531674-A | 1-heterocyclyl isochroman compounds and analogs for the treatment of CNS disorders | 赛诺维信制药公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-107001346-A | The base of 1 oxo, 1,2 dihydro-isoquinoline 7 bases of thiophene 2 of substitution (5) sulfonamide compounds, the preparation for containing those compounds and their purposes as AICARFT inhibitor in treating cancer | 伊莱利利公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-105324380-A | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-02-10 | — | — | CN | disclosed |
| CN-105246890-A | Pyrrolo[2, 3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-01-13 | — | — | CN | disclosed |