Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24152469 | 0.81 | LMNA (0.50) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL353225 | 0.79 | LMNA (0.42) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL11037068 | 0.78 | LMNA (0.41) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL28865231 | 0.77 | LMNA (0.34) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL866289 | 0.76 | LMNA (0.53) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL10532645 | 0.76 | LMNA (0.53) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL1284277 | 0.76 | LMNA (0.53) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL22749300 | 0.76 | LMNA (0.39) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL14693972 | 0.76 | LMNA (0.39) | LMNAMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL24783971 | 0.76 | LMNA (0.39) | LMNAMAPTKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6607736-B2 | Endermic liniment comprising diethoxy ethyl succinate and humectant | SHISEIDO COMPANY, LTD. (JP) | 2003-08-19 | — | — | US | claimed |
| US-6455570-B1 | SUBSTITUTED POLYPYRROLIDONE COMPOUND, USEFUL FOR TREATMENT OF INFLAMMATORY NEOPLASTIC AND DEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2002-09-24 | — | — | US | disclosed |
| US-20020123635-A1 | Polypyrrolinone based inhibitors of matrix metalloproteases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123635-A1 | Polypyrrolinone based inhibitors of matrix metalloproteases | MMP9, MMP16, MMP3 | LMNA 3544/4885MAPT 2686/4885KMT2A 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.