Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15305671 | 0.77 | MEN1 (0.54) | NUDT1MAPTKMT2AMEN1CCNA2 | |
| SCHEMBL15305670 | 0.73 | NPC1 (0.56) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6277127 | 0.72 | MAPT (0.47) | MAPTKMT2AHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL16852189 | 0.72 | KMT2A (0.47) | MAPTKMT2AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL16463778 | 0.71 | NUDT1 (0.60) | NUDT1ALDH1A1HTR6 | |
| SCHEMBL15757956 | 0.70 | NUDT1 (0.50) | NUDT1ROCK1 | |
| SCHEMBL27302783 | 0.70 | KMT2A (0.50) | MAPTKMT2AHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL27552383 | 0.70 | PARP10 (0.42) | MAPTKMT2AHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL22557464 | 0.70 | ASIC3 (0.46) | MAPTKMT2AHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL16852232 | 0.69 | TSHR (0.46) | MAPTKMT2AHPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |