Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.62 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | RPS27 | P42677 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28043888 | 0.93 | TLR8 (0.62) | HRH4TLR8PTGDRNOS3NOS1 | |
| SCHEMBL28151182 | 0.91 | HRH4 (0.52) | HRH4TLR8ALDH1A1SMN1; SMN2PTGDR | |
| SCHEMBL28043714 | 0.89 | HRH4 (0.50) | HRH4TLR8ALDH1A1SMN1; SMN2PTGDR | |
| SCHEMBL28043933 | 0.89 | HRH4 (0.50) | HRH4TLR8ALDH1A1SMN1; SMN2PTGDR | |
| SCHEMBL17407827 | 0.88 | HRH4 (0.80) | HRH4TLR8HRH1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28043774 | 0.88 | HRH4 (0.49) | HRH4TLR8ALDH1A1SMN1; SMN2PTGDR | |
| SCHEMBL28043806 | 0.88 | ALDH1A1 (0.52) | HRH4TLR8ALDH1A1SMN1; SMN2PTGDR | |
| SCHEMBL28043943 | 0.87 | HRH4 (0.55) | HRH4TLR8ALDH1A1SMN1; SMN2NOS3 | |
| SCHEMBL28151135 | 0.87 | HRH4 (0.49) | HRH4TLR8ALDH1A1SMN1; SMN2 | |
| SCHEMBL28152083 | 0.86 | HRH4 (0.68) | HRH4TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | claimed |
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-106794181-A | MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions | 托马斯·黑勒戴药物研究基金会 | 2017-05-31 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |