Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 7/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28043956 | 0.88 | TGM2 (0.39) | HDAC1BCL2A1TGM2THRATHRB | |
| SCHEMBL17847687 | 0.86 | HDAC2 (0.38) | HDAC1BCL2A1HDAC2HDAC3TGM2 | |
| SCHEMBL14907833 | 0.84 | HDAC1 (0.46) | HDAC1BCL2A1TGM2THRATHRB | |
| SCHEMBL15942177 | 0.82 | THRA (0.38) | HDAC1BCL2A1HDAC2HDAC3TGM2 | |
| SCHEMBL15938644 | 0.78 | TGM2 (0.54) | HDAC1HDAC2HDAC3TGM2THRB | |
| SCHEMBL15938273 | 0.78 | MEN1 (0.43) | HDAC1HDAC2HDAC3TGM2 | |
| SCHEMBL15938387 | 0.78 | TGM2 (0.54) | HDAC1HDAC2HDAC3TGM2 | |
| SCHEMBL15941566 | 0.76 | BCL2A1 (0.51) | HDAC1BCL2A1HDAC2HDAC3FGFR4 | |
| SCHEMBL15941228 | 0.76 | EGFR (0.49) | BCL2A1LMNA | |
| Hydrochloric Acid SCHEMBL18249511 | 0.76 | TGM2 (0.53) | HDAC1HDAC2HDAC3TGM2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105188371-A | Erk inhibitors and uses thereof | CELGENE AVILOMICS RES INC | 2015-12-23 | — | — | CN | disclosed |